Janet A Houghton Selected Research

GANT 61

12/2016	Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing.
6/2014	Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding.
1/2013	Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells.
9/2011	Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.
8/2011	The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.
2/2011	Hedgehog signaling drives cellular survival in human colon carcinoma cells.
10/2010	cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells.

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Janet A Houghton Research Topics

Disease

14	Carcinoma (Carcinomatosis) 06/2014 - 08/2002
13	Neoplasms (Cancer) 12/2016 - 03/2004
7	Colonic Neoplasms (Colon Cancer) 12/2016 - 08/2002
3	Rhabdomyosarcoma 01/2007 - 10/2004
3	Colorectal Neoplasms (Colorectal Cancer) 12/2005 - 03/2004
1	Glioblastoma (Glioblastoma Multiforme) 01/2013
1	Prostatic Neoplasms (Prostate Cancer) 01/2013
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 09/2011
1	Thyroid Neoplasms (Thyroid Cancer) 09/2008
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 07/2007
1	Embryonal Rhabdomyosarcoma 01/2007
1	Alveolar Rhabdomyosarcoma 01/2007
1	Carcinogenesis 12/2005
1	Leukemia 09/2005
1	Cowpox 10/2004

Drug/Important Bio-Agent (IBA)

7	GANT 61IBA 12/2016 - 10/2010
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2010 - 08/2003
5	LigandsIBA 06/2010 - 08/2003
5	CaspasesIBA 01/2007 - 12/2003
4	Proteins (Proteins, Gene)FDA Link 01/2013 - 10/2004
3	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 06/2010 - 12/2005
3	Fluorouracil (Carac)FDA LinkGeneric 09/2004 - 08/2002
3	Leucovorin (Folinic Acid)FDA Link 09/2004 - 08/2002
2	LuciferasesIBA 01/2013 - 08/2011
2	Messenger RNA (mRNA)IBA 01/2013 - 08/2011
2	cyclopamineIBA 09/2011 - 08/2011
2	NF-kappa B (NF-kB)IBA 06/2010 - 01/2006
2	CytokinesIBA 06/2008 - 10/2004
2	CeramidesIBA 01/2007 - 12/2005
2	Proteasome InhibitorsIBA 01/2006 - 09/2005
2	TNF-Related Apoptosis-Inducing LigandIBA 01/2006 - 03/2005
2	Casein Kinase II (Casein Kinase 2)IBA 03/2005 - 10/2004
2	Dichlororibofuranosylbenzimidazole (DRB)IBA 03/2005 - 10/2004
2	Protein Kinases (Protein Kinase)IBA 03/2005 - 10/2004
2	ZD 9331IBA 09/2004 - 12/2003
2	Interferon-gamma (Interferon, gamma)IBA 03/2004 - 12/2003
1	Transcription Factors (Transcription Factor)IBA 12/2016
1	AntibodiesIBA 01/2013
1	ChromatinIBA 01/2013
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2013
1	EnzymesIBA 01/2013
1	ABT-737IBA 09/2011
1	Drug CombinationsIBA 09/2011
1	navitoclaxIBA 09/2011
1	U 0126 (UO 126)IBA 08/2011
1	Complementary DNA (cDNA)IBA 10/2010
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 06/2010
1	Quinacrine (Mepacrine)IBA 06/2010
1	Adenosine Triphosphate (ATP)IBA 09/2008
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 06/2008
1	CGC 11093IBA 06/2008
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2008
1	PolyaminesIBA 06/2008
1	lexatumumabIBA 07/2007
1	Monoclonal AntibodiesIBA 07/2007
1	Histone Deacetylases (Histone Deacetylase)IBA 07/2007
1	Vorinostat FDA Link 07/2007
1	Imatinib Mesylate (Gleevec)FDA Link 07/2007
1	Histone Deacetylase InhibitorsIBA 07/2007
1	erythro-(2R,3S)-sphingosineIBA 01/2007
1	Protein Isoforms (Isoforms)IBA 01/2007
1	SphingosineIBA 01/2007
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 12/2005
1	CholesterolIBA 12/2005
1	Caspase 8 (Caspase-8)IBA 12/2005
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2005
1	NocodazoleIBA 09/2005
1	Caspase InhibitorsIBA 09/2005
1	Pharmaceutical PreparationsIBA 09/2005
1	Etoposide (VP 16)FDA LinkGeneric 09/2005
1	Proteasome Endopeptidase Complex (Proteasome)IBA 09/2005
1	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2005
1	Casein Kinase I (Casein Kinase 1)IBA 11/2004
1	InterleukinsIBA 10/2004
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 10/2004
1	5,6-dichlorobenzimidazoleIBA 10/2004
1	InterferonsIBA 09/2004
1	Thymidylate SynthaseIBA 09/2004
1	SurvivinIBA 12/2003
1	Protein Kinase CIBA 08/2003
1	rottlerinIBA 08/2003
1	RNA (Ribonucleic Acid)IBA 08/2002
1	Death Domain ReceptorsIBA 08/2002

Therapy/Procedure

3	Therapeutics 06/2014 - 08/2002